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Hasan babazada klib12/28/2023 Due to the unique molecular target profile different from buprenorphine, it might have important value in studying the mechanisms of morphine dependence and developing novel therapeutic approaches. Dezocine had affinity to norepinephrine and serotonin transporters and sigma-1 receptor, whereas buprenorphine showed no activity against these targets.ĭezocine could potentially be used to alleviate opioid dependence. Dezocine blocked the agonist-induced KOR internalization in vitro, 1 of the mechanisms involved in the downstream signaling and development of opioid dependence. Chronic morphine administration induced astrocytes activation in nucleus accumbens, which was attenuated by dezocine. 0001 by 2-way ANOVA) compared to the control group. Furthermore, dezocine inhibited the reinstatement of morphine-induced CPP (mean difference: 314 95% CI, 197.9-430.1 P <. Significance was observed at all treatment days, including day 7 (mean difference: 2.13 95% CI, 0.68-3.58 P <. kg dezocine compared to vehicle-treated control animals starting from the day 1 (mean difference: 7.8 95% confidence interval, 6.35-9.25 P MGIMO University (Moscow State Institute of International Relations) LL.M. The mean withdrawal score was reduced in rats treated with 1.25 mg Academic Advisor (Law Program) Email : Office : D326 Education: LL.B. Buprenorphine and dezocine were screened against 44 G-protein-coupled receptors, ion channels, and transporter proteins using radioligand-binding assay to compare the molecular targets. Effect of dezocine and buprenorphine on the internalization of κ opioid receptor (KOR) was investigated using Neuro2A expressing KOR fused to red fluorescent protein tdTomato (KOR-tdT). The astrocytes activation in nucleus accumbens was assessed by immunofluorescence assay of glial fibrillary acidic protein. Buprenorphine and vehicle solution containing 20% (v/v) dimethyl sulfoxide were used for positive and negative control, respectively. Effect of dezocine on morphine withdrawal syndrome and CPP was analyzed using 2-way analysis of variance (ANOVA) followed by Tukey's post hoc test. This study investigates the potential therapeutic effect of dezocine, a nonaddictive opioid, in opioid dependence in rat models.ĭezocine was administered intraperitoneally to a morphine-dependent rat model to investigate its effect on withdrawal and conditioned place preference (CPP). In 1986 he finished his bachelor's degree in international relations from Padjadjaran University in Bandung, Indonesia.Opioid dependence is a major public health issue without optimal therapeutics. Kleib received his master's degree in foreign affairs and trade at Monash University, Australia, in 1997. A career diplomat, Kleib joined the Department of Foreign Affairs in 1987. From 1988 to 1992, he was head of the Middle East Section in the Department of Foreign Affairs. He served as head of the disarmament section at the Department of Foreign Affairs, in Jakarta, from 1996 to 2000, and before that, from 1992, he was part of the political staff at Indonesia’s Permanent Mission to the United Nations. Prior to that, from 2000 to 2004, he was head of the political division at the Indonesian embassy in Washington, D.C. įrom 2004 to 2006, Kleib served as director for international security and disarmament affairs at the Department of Foreign Affairs, in Jakarta. Prior to his appointment, from 2007, Kleib was chargé d'affaires and deputy permanent representative of Indonesia to the United Nations, which included serving as deputy for his country during its non-permanent membership on the Security Council from 2007 to 2008. Research Associate at Penn Radiology 1mo University of Pennsylvania 458,594 followers 1mo Marking her first official Move-In experience at Penn, President Liz Magill. Facebook gives people the power to share and makes the world more open and connected. He served as the permanent representative of the Republic of Indonesia to the United Nations in New York from August 2010. Join Facebook to connect with Hassan Babazada and others you may know. Previously, he was the director general of multilateral affairs of Indonesia. Hasan Kleib, (born 1 October 1960 in Cirebon, West Java ) is an Indonesian diplomat and the current permanent representative of the Republic of Indonesia to the United Nations, World Trade Organizations, and other international organizations in Geneva from March 2017.
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